GeMCRIS - Vector Hierarchy Reports
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Vector Hierarchy Reports
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Term Name Definition View Report
_Study Design Terms   Category of terms related to various gene transfer study designs.   View
Adeno-associated virus 1 (AAV1) gene transfer vector   A human dependovirus [parvovirus] of serotype 1 that requires the presence of a helper virus (frequently Adenovirus) for productive infection. The linear single-stranded DNA genome of about 5000 nucleotides is packaged into an icosahedral particle of 20–24 nm in diameter. The capsid consists of three structural proteins, VP1, VP2 and VP3, in a ratio of 1:1:20 respectively.   View
Adeno-associated virus 2 gene transfer vector   A human dependovirus [parvovirus] of serotype 2 that requires the presence of a helper virus (frequently Adenovirus) for productive infection. The linear single-stranded DNA genome of about 5000 nucleotides is packaged into an icosahedral particle of 20–24 nm in diameter. The capsid consists of three structural proteins, VP1, VP2 and VP3, in a ratio of 1:1:20 respectively.   View
Adeno-associated virus 6 gene transfer vector   A human dependovirus [parvovirus] of serotype 6 that requires the presence of a helper virus (frequently Adenovirus) for productive infection. The linear single-stranded DNA genome of about 5000 nucleotides is packaged into an icosahedral particle of 20–24 nm in diameter. The capsid consists of three structural proteins, VP1, VP2 and VP3, in a ratio of 1:1:20 respectively.   View
Adeno-associated virus gene transfer vector   Adeno-associated viruses (AAV) are non-pathogenic human "dependoviruses" [parvoviruses], dependant on a helper virus, usually adenovirus, to proliferate. They are capable of infecting both dividing & non dividing cells, & in the absence of a helper virus, can integrate into a specific point of the host genome (19q 13-qter). The wild type genome is a single stranded DNA molecule, consisting of two genes; rep, coding for proteins which control viral replication, structural gene expression & integration into the host genome, & cap, which codes for capsid structural proteins.   View
Adeno-associated virus gene transfer vector pseudotypes   Adeno-associated virus (AAV) gene transfer vectors belonging to this subcategory are modified to contain viral components from more than one serotype (for example: mixtures of viral capsids from different AAV serotypes in a given viral particle).   View
Adenoviral gene transfer vectors   Derived from adenoviruses and used for studies of gene transfer. Adenoviral vectors are usually deleted for one or more early viral genes (most commonly E1and E3 deleted). Because of these deletions, these vectors require specialized cell lines (so-called "producer cells") in which to propagate.   View
Adenovirus helper-dependent (gutted) gene transfer vector   An adenovirus vector that has been completely gutted all of the viral genes from the virus. The vector is unable to replicate without a helper because its replication machinery is gutted, along with nearly everything else—save its ends, the therapeutic DNA, and the DNA sequence that enables it to package the newly replicated DNA into new virus particles.   View
Adenovirus serotype 2 gene transfer vector   A group C adenovirus. Gene therapy vectors derived from subgroup C adenoviruses of the serotype 2   View
Adenovirus serotype 2 replication competent gene transfer vector   The genotype or phenotype that is found in nature or in the standard laboratory stock for a given organism. The phenotype of a particular organism when first seen in nature.   View
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